What is lipemia Retinalis?

Lipemia retinalis (LR) is a retinal manifestation of chylomicronemia (hypertriglyceridemia). Ophthalmoscopic features are creamy-white discoloration of the retinal vessels, which start in the peripheral vessels in mild cases and involves central retinal vessels in established cases.

How does lipemia affect electrolytes?

Considering 0-350 mg% of triglyceride as the reference, electrolytes concentration mostly decreased over increasing lipemia. Beyond triglyceride concentration of 650mg%, this decline in electrolytes concentration was statistically significantly for samples in all subgroups.

Does lipemia cause hemolysis?

Hemolysis: Hemolysis of erythrocytes is enhanced in the presence of lipemia. This can affect results of individual tests (particularly end point reactions that are not blanked), because hemoglobin will absorb at wavelengths used to detect reactions in the analyzer.

Does lipemia affect glucose?

Till now, some studies have investigated the effect of lipemia on biochemistry parameters with variable results. One study designed by Randall et al. showed lipemia interferences with determination of glucose, phosphorus, total bilirubin, uric acid, and total protein by the Beckman Synchron CX5 [22].

What causes Lipaemia?

The most common preanalytical cause of lipemia is inadequate time of blood sampling after the meal. In the hospital setting a certain proportion of lipemic samples can’t be avoided, since patients are admitted to the emergency services in various times of the day and various intervals since their last meal.

Why is it called Dysbetalipoproteinemia?

In fact, the name “dysbetalipoproteinemia” stems from the abnormal gel electrophoresis migration pattern of VLDL, identified as a broad-β band, which is continuous from the β to pre-β levels (Fredrickson et al., 1967; Mahley and Rall, 1995).

What is the clinical significance of turbid or lipemic serum?

In the clinical laboratory setting, interferences can be a significant source of laboratory errors with potential to cause serious harm for the patient. After hemolysis, lipemia is the most frequent endogenous interference that can influence results of various laboratory methods by several mechanisms.

How do you reduce lipemia?

Aerobic exercise conducted 11–20 hours before the test meal appears to produce the greatest magnitude of reduction in postprandial lipemia compared to aerobic exercise conducted 30 minutes to 4 hours before a test meal [65, 66].

How is lipemia treated?

Centrifugation. A recommended procedure for treating lipemic samples is centrifugation using ultracentrifuge which effectively removes lipids and allows measurement of large number of analytes (42,43). However, due to the high cost, this equipment it is not available in a large number of laboratories.

How do you get rid of lipemia?

Conclusions: High-speed centrifugation (10,000×g for 15 minutes) can be used instead of ultracentrifugation to remove lipemia in serum/plasma samples. LipoClear and 1,1,2-trichlorotrifluoroethane are unsuitable as they interfere with the measurement of certain parameters.

Is Hyperlipoproteinemia curable?

Hyperlipidemia is treatable, but it’s often a life-long condition. You’ll need to watch what you eat and also exercise regularly. You might need to take a prescription medication, too. The goal is to lower the harmful cholesterol levels.

What is Type 4 hyperlipidemia?

Type 4 is a dominantly inherited disorder. It’s characterized by high triglycerides contained in VLDL. The levels of cholesterol and phospholipids in your blood usually remain within normal limits. Type 5 runs in families. It involves high levels of LDL alone or together with VLDL.