How do you use the Cockcroft-Gault equation?
The Cockcroft-Gault formula for estimating creatinine clearance (CrCl) should be used routinely as a simple means to provide a reliable approximation of residual renal function in all patients with CKD. The formulas are as follows: CrCl (male) = ([140-age] × weight in kg)/(serum creatinine × 72)
How does obesity affect CrCl?
in the CRIC study; higher BMI was associated with higher 24-hour urine creatinine excretion (and hence creatinine generation). For instance, women and men with class III (BMI ≥ 40 kg/m2) obesity had 31% and 34% higher creatinine excretion than women and men with normal BMI (18.5–24.9 kg/m2).
What weight does Cockcroft-Gault use?
Over the next few decades, the original Cockcroft-Gault equation was modified to use ideal body weight (=2.3 kg*each inch over 5 feet + W; W= 50 kg for males; 45.5 kg for females). If a patient’s actual body weight was less than his or her ideal weight, then actual weight should be used.
Is eGFR accurate in obese patients?
Conclusions. This study shows that, in obese CKD patients, the performance of eGFRCKD-EPI is good for GFR≤60 ml/min per 1.73 m2.
Does weight loss improve GFR?
Weight loss has been shown to improve renal function with decreased proteinuria, glomerular hyperfiltration and inflammation, and improved blood pressure and blood glucose control for individuals with and without overt renal disease.
How do you calculate ideal body weight?
Ideal body weight is computed in men as 50 + (0.91 × [height in centimeters − 152.4]) and in women as 45.5 + (0.91 × [height in centimeters − 152.4]). A simple alternative would be to compute ideal body weight as the weight corresponding to an ideal body mass index of 22 kg/m2.
What is normal creatinine clearance level?
Normal Results Clearance is often measured as milliliters per minute (mL/min) or milliliters per second (mL/s). Normal values are: Male: 97 to 137 mL/min (1.65 to 2.33 mL/s). Female: 88 to 128 mL/min (1.496 to 2.18 mL/s).
How do you calculate actual body weight?
Remember that BMI = weight(kg)/height2 (meters squared). Next, we will establish an ‘ideal’ BMI based on values in the standard IBW equations: Male: 60 inches – 50kg – BMI= 21.53. Female: 60 inches – 45.5kg – BMI= 19.59.
Does BMI affect eGFR?
Numerous studies have demonstrated an association between obesity and chronic kidney disease (CKD) . Higher body mass index (BMI) has been associated with lower estimated glomerular filtration rate (eGFR), loss of eGFR over time, and incident end-stage renal disease (ESRD).
Is the Cockcroft Gault equation accurate for obesity?
The reliance of the Cockcroft-Gault equation on weight as a key variable has reduced its accuracy in patients with obesity. Improved approaches to body-size description using LBW provide an opportunity to improve this equation.
Is the Cockcroft-Gault formula adjusted for body surface area?
Cockcroft-Gault Formula. The Cockcroft and Gault formula (CG) was developed in 1973 using data from 249 men with creatinine clearance (CCr) from approximately 30 to 130 mL/m2. It is not adjusted for body surface area. CG is no longer recommended for use because it has not been expressed using standardized creatinine values.
When was the Cockcroft and Gault CG formula created?
The Cockcroft and Gault formula (CG) was developed in 1973 using data from 249 men with creatinine clearance (CCr) from approximately 30 to 130 mL/m2. It is not adjusted for body surface area. CG is no longer recommended for use because it has not been expressed using standardized creatinine values.
Which is better MDRD or Cockcroft Gault formula?
Multiple studies have compared the equations for their impact on drug dosages. In the few studies that compared estimated GFR from the various equations to measured GFR, the studies have shown that the MDRD Study or CKD-EPI equation had greater concordance with measured GFR than the Cockcroft-Gault.