Why has danazol been discontinued?

The other manufacturer, Mylan, have identified a problem with the active pharmaceutical ingredient (API) which has led to the discontinuation of danazol capsules within the UK and supplies of both strengths are now exhausted.

Is danazol a steroid?

Danocrine (danazol) is a synthetic steroid with multiple and diverse biologic effects. It exerts these effects by binding to steroid transport proteins in the circulation and to specific receptors in target tissues. Centrally, danazol inhibits gonadotropins, suppressing gametogenesis and steroidogenesis.

How long can you take danazol?

It is essential that therapy continue uninterrupted for 3 to 6 months but may be extended to 9 months if necessary. After termination of therapy, if symptoms recur, treatment can be reinstituted.

Does danazol cause hair loss?

Mild hirsutism, edema, hair loss, voice change, which may take the form of hoarseness, sore throat or of instability or deepening of pitch, may occur and may persist after cessation of therapy.

What is danazol used for?

Danazol is in a class of medications called androgenic hormones. It works to treat endometriosis by shrinking the displaced tissue of the uterus. It works to treat fibrocystic breast disease by blocking the release of hormones that cause the breast pain and lumps.

Is danazol still available?

DANOCRINE (danazol) Capsules, 50 mg, 100 mg, and 200 mg, were discontinued from sale in December 2004. FDA moved the product to the “Discontinued Drug Product List” section of the Orange Book at that time.

Who should not take danazol?

Danazol must not be taken by women who are pregnant or who could become pregnant. Danazol may harm the fetus. You will need to have a negative pregnancy test before you begin taking this medication. Start taking this medication during your menstrual cycle to be sure you are not pregnant.

Is danazol a hormone?

Danazol is a synthetic androgen [1]. Androgens are hormones produced by the male testes. They are responsible for the functioning of the male reproductive system and the development of the male characteristics, such as facial hair and a deep voice.

What is danazol tablet used for?

Danazol is used to treat endometriosis (a condition in which the type of tissue that lines the uterus [womb] grows in other areas of the body and causes infertility, pain before and during menstrual periods, pain during and after sexual activity, and heavy or irregular bleeding)..

Does danazol stop menstruation?

Danazol suppresses oestrogen and progesterone receptors in the endometrium, leading to endometrial atrophy (thinning of the lining of the uterus) and reduced menstrual loss and to amenorrhoea in some women.

Who manufactures danazol?

Lannett Company
Learn more about Danazol | Lannett Company.

What is danazol for?

How should I take danazol?

read the manufacturer’s printed information leaflet from inside the pack.

  • You should start taking danazol on the first day of your next period unless you have been told otherwise.
  • and when you should take them.
  • Is Danazol an anabolic steroid medication?

    Danazol has a complex mechanism of action, and is characterized as a weak androgen and anabolic steroid, a weak progestogen, a weak antigonadotropin, a weak steroidogenesis inhibitor, and a functional antiestrogen. Danazol was discovered in 1963 and was introduced for medical use in 1971.

    What is the rationale for using danazol for endometriosis?

    Danazol can help treat endometriosis by stopping the growth and function of that endometrial tissue. It has this effect because it blocks the production of certain hormones that cause menstruation and growth of endometrial tissue.

    Can danazol cause breast pain?

    Danazol, tamoxifen, and gonadorelin analogues (goserelin) may reduce breast pain, but all can cause adverse effects. These agents would usually be prescribed only by a subspecialist. Danazol can cause weight gain, deepening of the voice, menorrhagia, and muscle cramps, and has androgenic effects on a fetus.