What is Tigan Injection used for?
Tigan (trimethobenzamide hydrochloride) Injectable is an anticholinergic drug used to treat nausea and vomiting.
Is Tigan still available?
Pfizer discontinued oral Tigan. They expect supplies to be depleted by May 2021. Trimethobenzamide injection is not affected by this shortage.
What happens if you give Tigan IV?
There have been instances of hypotension reported following parenteral administration to surgical patients. There have been reports of blood dyscrasias, blurring of vision, coma, convulsions, depression of mood, diarrhea, disorientation, dizziness, drowsiness, headache, jaundice, muscle cramps and opisthotonos.
What kind of medication is Tigan?
Tigan (trimethobenzamide hydrochloride) Capsules is an antiemetic indicated for the treatment of postoperative nausea and vomiting, and for nausea associated with gastroenteritis.
Where do you inject Tigan?
Intramuscular administration may cause pain, stinging, burning, redness and swelling at the site of injection. Such effects may be minimized by deep injection into the upper outer quadrant of the gluteal region, and by avoiding the escape of solution along the route.
Is Tigan a controlled substance?
Tigan is used in the treatment of nausea/vomiting and belongs to the drug class anticholinergic antiemetics. FDA has not classified the drug for risk during pregnancy. Tigan 250 MG is not a controlled substance under the Controlled Substances Act (CSA).
Why was Tigan discontinued?
Trimethobenzamide is available as 300 mg capsules in generic forms and under the brand name Tigan. It is also available as a solution for injection (100 mg/mL). Trimethobenzamide used to be available also as suppositories, but this formulation was discontinued due to lack of efficacy.
Why is Tigan being discontinued?
Reason for shortage: All generic trimethobenzamide oral capsules have been discontinued. Pfizer did not provide a reason for the shortage of Tigan capsules. Trimethobenzamide injection is not affected by this shortage.
Can you give Tigan IV push?
Trimethobenzamide injection is for intramuscular administration only; do not give via intravenous administration. Trimethobenzamide injection is contraindicated for use in children or infants.
What are the side effects of Tigan?
Diarrhea, headache, dizziness, drowsiness, or blurred vision may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
How is Tigan administered?
NOTE: The injectable form is intended for intramuscular administration only; it is not recommended for intravenous use. Intramuscular administration may cause pain, stinging, burning, redness and swelling at the site of injection.
What kind of preservative is in Tigan injection?
Multi-Dose Vials: Each mL contains 100 mg trimethobenzamide hydrochloride compounded with 0.45% phenol as preservative, 0.5 mg sodium citrate and 0.2 mg citric acid as buffers and pH adjusted to approximately 5.0 with sodium hydroxide.
How much Trimethobenzamide is in a Tigan capsule?
It has a molecular weight of 424.93 and the following structural formula: Each 300-mg Tigan capsule for oral use contains 300 mg trimethobenzamide hydrochloride (equivalent to 274.3 mg of trimethobenzamide) as the active ingredient.
What’s the dosage of Tigan for an adult?
Usual Adult Dosage. 2 mL (200 mg) t.i.d. or q.i.d. intramuscularly. NOTE: The injectable form is intended for intramuscular administration only; it is not recommended for intravenous use. Intramuscular administration may cause pain, stinging, burning, redness and swelling at the site of injection.
What is the mechanism of action of Tigan?
The mechanism of action of Tigan® as determined in animals is obscure, but may involve the chemoreceptor trigger zone (CTZ), an area in the medulla oblongata through which emetic impulses are conveyed to the vomiting center; direct impulses to the vomiting center apparently are not similarly inhibited.