What is the function of human keratin 18?
Keratin 18 is often used together with keratin 8 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.
What is E cadherin positive?
A negative E-cadherin stain was a sensitive and specific biomarker to confirm the diagnosis of invasive lobular carcinoma (specificity 97.7%; negative predictive value 96.8%; sensitivity 88.1%; and positive predictive value 91.2%). Positive E-cadherin expression was also associated with tubulolobular carcinomas.
How is CK8 / 18 used as a staining mask?
CK8/18 rabbit monoclonal may be useful as a staining mask in a multiplex stain with mouse monoclonal antibodies such as Ki-67, PD-1 or CD8. As CK8/18 does not stain stromal components or tumor infiltrating lymphocytes in various carcinomas such as breast or colon cancers, a CK8/18 staining mask may be helpful with these applications.
What kind of antibody is cytokeratin 8 / 18?
Cytokeratin (8/18) Cytokeratin (8/18) – IHC Primary Antibodies It appears that your browser has JavaScript disabled. This Website requires your browser to be JavaScript enabled. Please enable JavaScript and reload this page.
Why is CK8 / 18 important in neoplastic tissues?
In normal tissues, CK8/18 recognizes all simple and glandular epithelium (1). In neoplastic tissues, CK8/18 may prove useful for the identification of most adenocarcinomas and some squamous cell carcinomas. CK8/18 expression patterns may also aid in the classification of tumors of unknown origin and poorly differentiated carcinomas…
Can a CK8 / 18 mask be used for colon cancer?
As CK8/18 does not stain stromal components or tumor infiltrating lymphocytes in various carcinomas such as breast or colon cancers, a CK8/18 staining mask may be helpful with these applications. 1. Moll R, Divo M, Langbein L.