What is pluronic f 68?

Gibco® Pluronic® F-68 is a non-ionic surfactant used to control shear forces in suspension cultures. Pluronic® F-68 can also be used to reduce foaming in stirred cultures and reduce cell attachment to glass. Pluronic® F-68 is provided at a concentration of 10% and effective at a working concentration of 0.1%.

What is pluronic F68 used for?

Pluronic F68 is used in cell culture as a stabilizer of cell membranes protecting from membrane shearing and additionally acts as an anti-foaming agent.

What is polyoxyethylene polyoxypropylene block copolymer?

Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)). Poloxamers are also known by the trade names Pluronic, Kolliphor (pharma grade), and Synperonic.

What is P188?

Poloxamer 188 (P188) is a nonionic linear copolymer having an average molecular weight of 8400 Daltons and is also referred to as PLURONIC F68, FLOCOR and RheothRx. The copolymer was approved by the FDA nearly 50 years ago as a therapeutic reagent to reduce viscosity in the blood before transfusions.

What is Pluronic gel?

Description: Clear gel at room temperature, Pluronic Gel 20% is used in combination with Lipmax to form a PLO Gel for relatively low concentrations of actives ingredients (=<10%). Targeted malleability is obtained when stored between 2-8°C.

What is Pluronic water?

Pluronic F-127 *10% solution in water* is a nonionic, surfactant polyol (molecular weight approximately 12,500 daltons) that has been found to facilitate the solubilization of water-insoluble dyes and other materials in physiological media.

Is Pluronic a detergent?

Pluronic® F-127, PROTEIN GRADE® Detergent, 10% Solution, Sterile-Filtered Non-ionic detergent useful for isolation of membrane proteins.

Is Pluronic a poloxamer?

Poloxamer is an amphiphilic block copolymer, consisting of poly(ethylene oxide)-poly(propylene oxide)-poly(ethyelene oxide) triblock copolymer (PEO-PPO-PEO) as shown in Figure 32. It is more commonly called Pluronic® (BASF).

What is the difference between poloxamer 188 and 407?

PXM-188 is an ABA block type copolymer which contains around 80% POE units and 20% PPO units. PXM-407 is also an ABA block type copolymer, containing approximately 70% PEO and 30% PPO. PXM-407 exhibits reverse thermal gelation in concentrations above 20%, and has a non-toxic nature [6], [7].

Is Pluronic F127 toxic?

Pluronic F-127 (i.e., poloxamer) is water soluble and exhibits low toxicity30.

How do you dissolve a Pluronic F127?

Dissolve 1 g of Pluronic® F-127 in 10 mL distilled water to make a 10% (w/v) stock solution, or 2 g of Pluronic® F-127 in 10 mL of anhydrous dimethyl sulfoxide (DMSO) to make a 20% (w/v) stock solution. These may require heating from 40 to 50 °C for about 30 minutes. Store solution at room temperature.