What is in a vial of Thiopentone?
Each vial contains 500mg Thiopental Sodium (as Thiopental Sodium and Sodium Carbonate Ph. Eur.) Powder for solution for injection in a vial (Powder for Injection). Yellow-white freeze dried powder.
How do you mix thiopental?
Solutions may be prepared by adding thiopental to 5% water solution of dextrose or to 0.9% solution of sodium chloride. Since Thiopental Injection contains no added bacteriostatic agent, extreme care in preparation and handling should be exercised at all times to prevent the introduction of microbial contaminants.
How do you dissolve thiopental?
Method of Administration For injection anaesthesia, Thiopental Panpharma is dissolved in water for injection or 0.9% sodium chloride solution and subsequently slowly injected intravenously (see section 4.4). Repeat injections may be performed.
What is the starting material for the synthesis of thiopental sodium?
Thiopental, 5-ethyl-5-(1-methylbutyl)2-thiobarbituric acid (1.2. 10), is synthesized by the alkylation of ethylmalonic ester with 2-bromopentane in the presence of sodium ethoxide. The product ethyl-(1-methylbutyl)malonic ester (1.2.
What schedule is thiopental?
Thiopental sodium is classified as a Schedule III controlled substance.
When is thiopental used?
Thiopental slows the activity of your brain and nervous system. Thiopental is used to help you relax before you receive general anesthesia with an inhaled medication.
Is thiopental water soluble?
Thiopental is the most commonly used barbiturate and is derived from barbituric acid, a condensation product of urea and malonic acid. It is insoluble in water and is prepared in a carbonate salt to maintain an alkaline pH.
Is sodium thiopental illegal?
Sodium thiopental, an anesthetic widely used in executions prior to 2010, is no longer produced by any U.S. pharmaceutical manufacturers, and the FDA has said that it has no legal uses in the U.S. In January 2017, the Texas Department of Criminal Justice sued the FDA, demanding a final decision on the detained imports.
Is thiopental an anesthesia?
Sodium thiopental is an important and medically necessary anesthetic agent that has been used for years to induce anesthesia in patients undergoing surgical procedures.
How much sodium is in a vial of thiopental?
Each vial of Thiopental 1 g powder for solution for injection contains 1000 mg thiopental sodium (as thiopental sodium and sodium carbonate). Excipients with known effect: Each vial of Thiopental sodium 500 mg contains 2.2-2.4 mmol sodium (51-56 mg). Each vial of Thiopental sodium 1000 mg contains 4.4-4.9 mmol sodium (102-112 mg).
How is thiopental used as an anticonvulsant?
Thiopental is a barbiturate, the structure of which is that of 2-thiobarbituric acid substituted at C-5 by ethyl and sec-pentyl groups. It has a role as an anticonvulsant, a sedative, an environmental contaminant, a xenobiotic, a drug allergen and an intravenous anaesthetic. It derives from a 2-thiobarbituric acid.
How many mg of thiopental is needed for induction?
Moderately slow induction can usually be accomplished in a healthy female or male adult weighing 60-80 kg by injection of 50 to 75 mg of thiopental at intervals of 20 to 40 seconds, depending on the reaction of the patient. Once anesthesia is established, additional injections of 25 to 50 mg can be given whenever the patient moves.
Which is the correct structure of a thiopental?
NCI Thesaurus (NCIt) Thiopental is a barbiturate, the structure of which is that of 2-thiobarbituric acidsubstituted at C-5 by ethyl and sec-pentyl groups. It has a role as an anticonvulsant, a sedative, an environmental contaminant, a xenobiotic, a drug allergen and an intravenous anaesthetic. It derives from a 2-thiobarbituric acid.