What is anti HPA?
Anti-HPA-1a-antibodies are the main cause of fetal and neonatal alloimmune thrombocytopenia (FNAIT) which may result in intracranial hemorrhage (ICH) and death among fetuses and newborns.
What is HLA and HPA?
human leukocyte antigens (HLA) class I. human platelet antigens (HPA) or in some cases high titre ABO blood group antibodies.
What is HPA 1a negative?
Platelet-specific antigen-negative platelets (HPA-1a negative platelets) are used for alloimmune thrombocytopenia and neonatal alloimmune thrombocytopenia (NAIT). Platelet-specific antigen-negative platelets (HPA-1a negative platelets) are available under the following different brand names: N/A.
Do platelets cross the placenta?
Some of the baby’s platelets cross the placenta into the mother’s circulation. In some cases, the mother’s immune system reacts against the baby’s platelets because of the differences in HPA are seen as ‘foreign’.
What does it mean to test positive for HLA?
A positive result means HLA-B27 was found in your blood. You may have a higher-than-average risk of certain autoimmune diseases, such as ankylosing spondylitis and reactive arthritis.
What is hpa1a?