How common is translocation Down syndrome?
About 3 – 4% of people with Down Syndrome have translocation Down syndrome.
Does translocation cause birth defects?
In reciprocal translocations, nonhomologous Robertsonian translocations and homologous Robertsonian translocations, the birth defects rates were 5.7% (20/350), 10.9% (14/128) and 8.0% (2/25), respectively (P < 0.05).
Is translocation Down syndrome dominant or recessive?
Like cystic fibrosis, Down’s Syndrome is autosomal recessive. This means that the condition is genetic and passed down by the mother and/or the father but the condition is not shown in the parents. An autosomal recessive disorder requires two copies of the abnormal gene for the disease or trait to develop.
How do you fix translocation?
Treatment. There is no cure for balanced translocation, and in most cases, the only adverse effect on health is recurrent miscarriages.
How do you test for translocation?
Tests for chromosome translocations Genetic testing is available to find out whether a person carries a translocation. A simple blood test is done, and cells from the blood are examined in a laboratory to look at the arrangement of the chromosomes. This is called a karyotype test.
How is translocation treated?
How do you know if you have translocation?
Your geneticist will offer to test other members of your family to find out whether your translocation is a new one or a family one. A small blood sample is needed for the test. Testing both your parents may be enough but if that is not possible, other family members may also be invited for testing.
Where does Translocation Down Syndrome take place in the body?
Translocation Down syndrome happens when an extra copy of chromosome 21 is attached to another chromosome. This is then present in all cells of the body. Chromosomes contain all of the genetic information that tells our body how to grow and function.
Can a person with Translocation Down syndrome get pregnant?
However, it is possible that they may have trouble getting pregnant. Even though carriers have the right amount of genes, the egg or sperm may have either too much or too few genes. This may cause an unexpected miscarriage. What does translocation Down syndrome mean for me?
When does a baby have a balanced translocation?
If one parent has the translocation chromosome, then the doctor knows the baby inherited the translocation from that parent. When a person has a rearrangement of chromosome material, with no extra or missing chromosome material, he or she is said to have a “balanced translocation” or be a “balanced translocation carrier.”
How is the extra 21 chromosome related to Down syndrome?
The genetic material from the extra 21 chromosome is what causes the health problems that are caused by Down syndrome. In translocation Down syndrome, the extra 21 chromosome may be attached to the 14 chromosome, or to other chromosome numbers like 13, 15, or 22. In some cases, two 21 chromosomes can be attached to each other.