What is the therapeutic range for sertraline?

What is the therapeutic range for sertraline?

A dosage of 25 mg or 50 mg per day is the initial therapeutic dosage. For adults and pediatric patients, subsequent dosages may be increased in case of an inadequate response in 25 to 50 mg per day increments once a week, depending on tolerability, up to a maximum of 200 mg per day.

What does sertraline do to blood?

Among SSRIs, those with the higher degree of serotonin reuptake inhibition, fluoxetine, paroxetine, and sertraline are more frequently associated with abnormal bleeding (2). SSRI use is associated with doubled risk of upper GI bleeding; bleeding at other sites has been less commonly reported (1).

Does sertraline affect concentration?

Essentially, the study found that sertraline did not appear to improve depressive symptoms, which include low mood, loss of pleasure, and poor concentration, within 6 weeks, although weak evidence indicated those results by 12 weeks.

What is the pharmacokinetics of sertraline?

Sertraline is eliminated from the body by other metabolic pathways to form a ketone and an alcohol, which are largely excreted renally as conjugates. The elimination half-life of sertraline ranges from 22-36 hours, and once-daily administration is therapeutically effective.

Is sertraline bad for kidneys?

For people with kidney problems: If you have kidney problems or a history of kidney disease, you may not be able to clear this drug from your body well. This may increase the levels of this drug in your body and cause more side effects. This drug may also decrease your kidney function, making your kidney disease worse.

What’s the highest dose of sertraline you can take?

Therapeutic Range: Not well established. Toxic: > 300 ng/mL Sertraline doses ranging from 50-200 mg/d produce serum concentration ranging from 30-200 ng/mL. Dosing above 200 mg/d is associated with increased adverse effects and decreased efficacy. Adverse effects may include dry mouth, headache, dizziness, somnolence, nausea and diarrhea.

When does sertraline reach its peak plasma concentration?

Kinetics: Absorption by route of exposure: Sertraline is slowly and completely absorbed from the gastrointestinal tract. Peak plasma concentrations (Cmax) occur between 4.5 and 8.5 hours after ingestion of a single dose.

What are the effects of sertraline on cortisol levels?

Baseline levels of triiodothyronine (T(3)) were lower, while cortisol, prolactin (PRL), thyroid-stimulating hormone (TSH), and thyroxin (T(4)) levels did not differ from the values in 16 female controls. There was a positive correlation between the scores on the Montgomery-Asperg Depression Rating Scale and baseline cortisol levels.

What is the molecular weight of sertraline PubChem?

Sertraline PubChem CID 68617 Synonyms sertraline 79617-96-2 (1S,4S)-4- Molecular Weight 306.2 Date s Modify 2021-06-12 Create 2005-06-24