What does PPAR-alpha do?
Peroxisome proliferator-activated receptor (PPAR)-alpha is a ligand-activated transcriptional factor that belongs to the family of nuclear receptors. PPAR-alpha regulates the expression of genes involved in fatty acid beta-oxidation and is a major regulator of energy homeostasis.
Where are PPAR-alpha receptors?
In rodents, highest mRNA expression levels of PPAR-alpha are found in liver and brown adipose tissue, followed by heart and kidney. Lower PPAR-alpha expression levels are found in small and large intestine, skeletal muscle and adrenal gland.
Which drug activates PPAR-alpha?
PPARs are activated by fatty acids and eicosanoids , as well as by small molecules, such as fibrates for PPAR-α, GW501516, GW0742, bezafibrate and Telmisartan for PPAR-β/δ, and glitazones for PPAR-γ.
Which drug is PPAR-alpha agonist?
PPAR-alpha agonists PPARα (alpha) is the main target of fibrate drugs, a class of amphipathic carboxylic acids (clofibrate, gemfibrozil, ciprofibrate, bezafibrate, and fenofibrate).
What is Pparα What is its clinical significance?
PPARα is highly expressed in metabolically active tissues, such as liver, heart, skeletal muscle, intestinal mucosa and brown adipose tissue. This receptor is implicated in fatty acid metabolism and its activation lowers lipid levels [12-15].
How do PPAR alpha agonists work?
PPARγ agonists promote adipocyte differentiation, and they promote FFA uptake and storage in subcutaneous adipose rather than visceral adipose tissue. This reduces FFA levels, with associated reductions in insulin resistance.
What is PPAR medicine?
Pioglitazone decreases insulin resistance in the periphery and in the liver resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output. Pioglitazone is a potent and highly selective agonist for Peroxisome proliferator-activated receptor-gamma (PPARγ).
Which drugs are fibrates?
List of Fibric acid derivatives:
|Drug Name||Avg. Rating||Reviews|
|TriCor (Pro) Generic name: fenofibrate||5.9||15 reviews|
|Lopid (Pro) Generic name: gemfibrozil||6.5||6 reviews|
|Lipofen (Pro) Generic name: fenofibrate||7.3||2 reviews|
|Antara (Pro) Generic name: fenofibrate||2.0||1 review|
Which activity is mainly performed by Alpha oxidation process?
Alpha oxidation (α-oxidation) is a process by which certain fatty acids are broken down by removal of a single carbon from the carboxyl end. In humans, alpha-oxidation is used in peroxisomes to break down dietary phytanic acid, which cannot undergo beta-oxidation due to its β-methyl branch, into pristanic acid.
What are the benefits of PPAR?
Treatment with PPAR agonists can reduce the burden of atherogenic postprandial lipoproteins and improve vascular function, reduce inflammation and inhibit foam cell formation. All of these would be expected to have favorable effects on cardiovascular risk.
What are the target genes of PPAR alpha?
Gene expression profiling studies have indicated that PPAR-alpha target genes number in the hundreds. Classical target genes of PPAR-alpha include PDK4, ACOX1, and CPT1.
What is the role of peroxisome proliferator activated receptor alpha?
The peroxisome proliferator-activated receptor alpha (PPAR ) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis.
How is PPAR-alpha related to anticonvulsants?
PPAR-alpha may also be a site of action of certain anticonvulsants. PPAR-α governs biological processes by altering the expression of a large number of target genes. Accordingly, the functional role of PPAR-alpha is directly related to the biological function of its target genes.
What is the function of PPAR alpha in the liver?
Function. PPAR-alpha is a transcription factor and a major regulator of lipid metabolism in the liver. PPAR-alpha is activated under conditions of energy deprivation and is necessary for the process of ketogenesis, a key adaptive response to prolonged fasting. Activation of PPAR-alpha promotes uptake, utilization,…