## Is NPH and Lantus the same?

Glargine (Lantus) is an insulin analog recently available in the U.S. It is a long-acting insulin but differs from other long-acting insulins (such as NPH, Lente, and ultralente) because it is clear as opposed to cloudy. It also has an acidic pH and should not be mixed with other insulins.

How do you convert between insulins?

1. Substituting with an intermediate-acting insulin: Give 70% of total units for each dose.
2. Substituting with a long-acting insulin: Add up the total insulin units given in one day. Give 70% as one daily dose.

How do you calculate NPH and regular insulin?

Custom- mixed NPH and Regular Insulin Failed above pre-mix 70/30 regimen Calculate 0.5 units/kg/day body weight (total daily dose) AM dose = 2/3 of total daily dose given as custom-mix: 2/3 NPH and 1/3 Regular before breakfast 150-250 Increase AM NPH dose by 2 units. Greater than 250 Increase AM NPH dose by 4 units.

### Do you shake NPH insulin?

Patients on insulin known as NPH (Humulin N, Novolin N) are often reminded that they need to re-suspend it before use by shaking it or rolling it in the palm of their hand.

Should NPH insulin be given before meals?

The total daily dose is given as 1 to 2 injections per day, given 30 to 60 minutes before a meal or bedtime. Some patients may initially be given a single daily dose of 30 to 60 minutes before breakfast, but 24-hour blood glucose control may not be possible with this regimen.

Is NPH short or long acting?

Official Answer. No, NPH (Humulin N, Novolin N) insulin is considered an intermediate-acting insulin. NPH insulin has a longer duration of action than the rapid-acting insulins (Novolog, Apidra, Humalog) and the short-acting insulins (Humulin R, Novolin R).

#### What is the difference between regular insulin and NPH?

Insulins are categorized based on the onset, peak, and duration of effect (eg, rapid-, short-, intermediate-, and long-acting insulin). Insulin NPH (an isophane suspension of human insulin) and insulin regular is an intermediate-acting combination insulin product with a more rapid onset than that of insulin NPH alone.

What is the difference between novolin 70/30 and Lantus?

Official Answer. The main difference between these two insulins is that Novolog 70/30 – contains an intermediate acting and a very fast acting insulin, whereas Novolin 70/30 contains an intermediate acting insulin and a short acting insulin.

What happens if Lantus is not refrigerated?

In general, patients are instructed that once opened, an insulin vial need not be refrigerated and can be kept at room temperature for ∼1 month. Extremes of temperature should be avoided because these can lead to significant changes in insulin action.

## Can NPH be given with regular insulin?

When mixing insulin NPH with other preparations of insulin (eg, insulin aspart, insulin glulisine, insulin lispro, insulin regular), insulin NPH should be drawn into the syringe after the other insulin preparations. After mixing NPH with regular insulin, the formulation should be used immediately.

Is Toujeo the new Lantus?

Toujeo (Insulin Glargine U-300) Insulin Toujeo is not actually “new.” It simply is three times more concentrated than insulin glargine (Lantus), so you can inject a smaller volume of insulin to get the same effect. Most of the insulin available today comes in a U-100 concentration, including Lantus (glargine U-100).

What is insulin comparable to Lantus?

Both Levemir and Lantus are preferred over NPH insulin because they have a longer duration of action, a less pronounced peak, and are more consistent in their effects with less risk of hypoglycemia. Both Levemir and Lantus are clear solutions, unlike NPH which requires resuspension prior to injection.

### Which insulin is given first regular or NPH?

The traditional NPH insulin regimens use two injections of NPH per day. The first dose covers the day and the second dose covers the evening and night. With this basic regimen, Regular insulin also is given before breakfast and dinner. An alternative NPH regimen is to give Regular insulin alone at meals and NPH at bedtime.

Why do I take Lantus insulin at night?

Lantus is usually administered at night to bring your glucose levels down to normal in the morning. If you have abnormal glucose levels at bedtime, one philosophy is to bring them down to normal using a small amount of short acting insulin and then use the lantus to make sure they will be normal in the morning.