Is bazedoxifene a SERM?
Bazedoxifene is a selective estrogen receptor modulator (SERM) currently in development for osteoporosis prevention and treatment.
What is bazedoxifene acetate?
Bazedoxifene, used as bazedoxifene acetate, is a medication for bone problems and possibly (pending more study) for cancer. It is a third-generation selective estrogen receptor modulator (SERM).
Is bazedoxifene a hormone?
Bazedoxifene is not a hormone, but works by acting like estrogen (as a selective estrogen receptor modulator or SERM) in some parts of the body. The bazedoxifene in this medication helps to preserve bone mass and reduces the risk of cancer of the uterus which can be caused by using estrogen.
Is bazedoxifene available in India?
GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler, Supplier, Exporters from India of conjugated estrogens/bazedoxifene (Duavee) which is also known as Duavee and Manufactured by Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.. It is available in strength of . 45; 20 mg/1; mg/1.
What is Bijuva made of?
Bijuva contains two active drug ingredients: estradiol and progesterone. Estradiol is a type of estrogen hormone. Progesterone is a type of progestin hormone. Duavee also contains two active drug ingredients: conjugated estrogens and bazedoxifene.
Is Bijuva synthetic?
BIJUVA is the first and only bio-identical estradiol and bio-identical progesterone product offering women an alternative to the available FDA -approved synthetic (non-bio-identical) hormones, the separate FDA -approved bio-identical estrogen and progesterone products that are used together but are not approved for …
What are SERMs and their indications?
Selective estrogen receptor modulators (SERMs) are now being used as a treatment for breast cancer, osteoporosis and postmenopausal symptoms, as these drugs have features that can act as an estrogen agonist and an antagonist, depending on the target tissue.
What is the mechanism of action of bazedoxifene?
Bazedoxifene is an Estrogen Agonist/Antagonist. The mechanism of action of bazedoxifene is as a Selective Estrogen Receptor Modulator. Bazedoxifene is an indole derivative and third-generation selective estrogen receptor modulator (SERM) with potential antineoplastic activity.
How long does it take to absorb bazedoxifene?
Bazedoxifene is rapidly absorbed with a tmax of approximately 2 hours and exhibits a linear increase in plasma concentrations for single doses from 0.5 mg up to 120 mg and multiple daily doses from 1 mg to 80 mg. The absolute bioavailability of bazedoxifene is approximately 6%.
What is the bioavailability of bazedoxifene in urine?
The absolute bioavailability of bazedoxifene is approximately 6%. The major route of elimination of radio-labelled bazedoxifene is the faeces, and less than 1% of the dose is eliminated in urine. Following intravenous administration of a 3 mg dose of bazedoxifene, the volume of distribution is 14.7 ± 3.9 l/kg.